Our antibiotics are failing us. In 2025, the UK Government said antibiotic resistance (AMR) contributes to more than 35,000 deaths each year in the UK. Emergency doctors say they are losing patients on a regular basis when they run out of ways to treat them.

Antibiotics have saved countless lives, but alongside them, there is another unlikely sounding ally in this fight: viruses, so small that they can attack and kill the bacteria causing these devastating infections. They are called bacteriophages, or phages for short. There are more of them than any other commonly occurring natural entity on the planet. And we could be about to see doctors using them on very ill patients in the UK. The thing is scientists have studied bacteriophages for nearly a century. They are used routinely in other countries, and science journalist Marnie Chesterton, who has been following this story for nearly a decade, asks why, suddenly, is phage all the rage?

Have you ever been told you aren't good enough to do something, then gone ahead and proved the naysayers wrong by doing it anyway - in glorious, headline-grabbing style?

That is the satisfying story of Dr Dean Lomax. Dean grew up in Doncaster with a passion for fossils but after failing various school exams, was told by teachers that he'd never make it as a palaeontologist. Undeterred by leaving school with no qualifications, Dean sold his childhood Star Wars collection to fund a fossil-hunting trip to America that changed his life - after which a chance discovery led to him publishing his first ever scientific paper at the age of just 20.

Today, he’s an expert on ichthyosaurs - the massive marine reptiles that once inhabited our seas - and has discovered and named several new species, written books for both adults and children, and brought the prehistoric world to life on TV. Talking to Professor Jim Al-Khalili, Dean discusses dinosaurs as a 'gateway science', discovering the Rutland Sea Dragon and the importance of cutting out noise from nay-sayers to follow your dreams...

What if robots of the future weren’t just clever machines, performing tasks in isolation, but trusted teammates you could have a chat with? That could respond naturally to conversational cues and even explain their work? Making this relationship a reality is a focus for Helen Hastie, Professor of Human-Robot Interaction and Head of the School of Informatics at the University of Edinburgh. Helen’s career has taken her from developing early dialogue systems - the ancestors of today’s generative AI - to working on sophisticated bots that can serve coffee with a side of small-talk, teach struggling kids with empathy, or provide calm and confident decisions as triage nurses. She’s also driven some of the UK’s flagship robotics initiatives, including as co-lead of the National Robotarium. Talking to Professor Jim Al-Khalili - who reveals he was once told off for rudeness by an early chatbot - Helen explains her hopes for useful, reliable and ultimately trustworthy robots; machines that aren’t just in our world but a welcome part of it.

Dr Seth Berkley is an epidemiologist and global health leader whose career has been shaped by one central problem: vaccines save lives, but only if people can actually get them. His 40-year career has spanned the global, from helping to build Uganda’s first HIV surveillance system and founding the International AIDS Vaccine Initiative; to leading Gavi, the Vaccine Alliance for more than a decade – overseeing the immunisation of hundreds of millions of children worldwide. And when COVID-19 struck, Seth co-founded COVAX, the global initiative designed to stop wealthy nations monopolising vaccines. In conversation with Professor Jim Al-Khalili, Seth discusses the highs and lows of his globe-trotting career - from saving millions of young lives through vaccine distribution, to setting his own shattered leg after a climbing accident in Namibia - and addresses the huge challenge of tackling vaccine scepticism.

Hiranya Peiris is playing a starring role in a movie that promises to tell perhaps the greatest story of all time. However, it’s a movie with a difference – there’s no director and no script. The Legacy Survey of Space and Time is one of the most ambitious projects in the world of astronomy, with a mission to create a decade-long time-lapse movie of the visible universe, to answer fundamental questions about its origin, evolution and, ultimately, its fate.

Hiranya is Professor of Astrophysics 1909, the prestigious Chair at the Institute of Astronomy at Cambridge University. Over her career she’s been one of the pioneers of a revolution in astronomy, bridging fundamental physics with the observational data coming back from space, to establish the first evidence-based standard model for the origin, evolution and fate of the universe. The endeavour has transformed the field from the ‘wild west’ of physics to the modern era of precision cosmology.

Ironically, it was another movie, of sorts, Carl Sagan’s documentary series ‘Cosmos’, that first sparked Hiranya’s interest in the universe as a young girl. Always keen to inspire women to follow in her footsteps and choose careers in science, if this interview were a live show she’d have reserved the front row for schoolgirls.